ITM0318
ITM0318
- Catalog: ITM0318
- Gene/Protein: GSK3B
- Product Description: Immunotag™ GSK3β Monoclonal Antibody
504.0000
Price in reward points: 504
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | GSK3β |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,IF,FCM,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. Immunofluorescence: 1/200 - 1/1000. Flow cytometry: 1/200 - 1/400. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat,Monkey |
| Host Species | Mouse |
| Immunogen | Purified recombinant fragment of human GSK3β expressed in E Coli |
| Specificity | GSK3β Monoclonal Antibody detects endogenous levels of GSK3β protein. |
| Purification | Affinity purification |
| Form | Ascitic fluid containing 0.03% sodium azide. |
| Gene Name | GSK3B |
| Accession No. | P49841 Q9WV60 P18266 |
| Alternate Names | GSK3B; Glycogen synthase kinase-3 beta; GSK-3 beta; Serine/threonine-protein kinase GSK3B |
| Description | glycogen synthase kinase 3 beta(GSK3B) Homo sapiens The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009], |
| Cell Pathway/ Category | ErbB_HER,Chemokine,Cell_Cycle_G1S,Cell_Cycle_G2M_DNA,WNT,WNT-T CELLHedgehog,Axon guidance,Focal adhesion,T_Cell_Receptor,B_Cell_Antigen,Neurotrophin,Insulin_Receptor,Melanogenesis,Alzheimer's disease,Pathways in cancer,Colorectal cancer,Endometrial cancer,Prostate cancer,Basal cell carcinoma, |
| Protein Expression | Epithelium,Eye,Placenta,Platelet, |
| Subcellular Localization | nucleus,cytoplasm,mitochondrion,centrosome,cytosol,plasma membrane,postsynaptic density,growth cone,intracellular ribonucleoprotein complex,beta-catenin destruction complex,neuronal cell body,dendritic shaft,p |
| Protein Function | catalytic activity:ATP + [tau protein] = ADP + [tau protein] phosphate.,enzyme regulation:Inhibited when phosphorylated by AKT1.,function:Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin.,PTM:Phosphorylated by AKT1 and ILK1.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer (By similarity). Interacts with CABYR, MUC1, NIN and PRUNE.,tissue specificity:Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
| English_US |
|
| Danish |
|
| Dutch |
|
| English_UK |
|
| French |
|
| German |
|
| Spanish |
|
| Norwegian |
|
| Portuguese |
|
| Finnish |
|
| Swedish |
|
| Polish |
|