ITM0420
ITM0420
- Catalog: ITM0420
- Gene/Protein: LPL
- Product Description: Immunotag™ LPL Monoclonal Antibody
504.0000
Price in reward points: 504
| Antibody Specification | |
| Datasheet | 
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| Target Protein | LPL |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Purified recombinant fragment of LPL expressed in E. Coli. |
| Specificity | LPL Monoclonal Antibody detects endogenous levels of LPL protein. |
| Purification | Affinity purification |
| Form | Ascitic fluid containing 0.03% sodium azide. |
| Gene Name | LPL |
| Accession No. | P06858 P11152 |
| Alternate Names | LPL; LIPD; Lipoprotein lipase; LPL |
| Description | lipoprotein lipase(LPL) Homo sapiens LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Glycerolipid metabolism,PPAR,Alzheimer's disease, |
| Protein Expression | Adipose tissue,Brain,Milk,Placenta, |
| Subcellular Localization | extracellular region,extracellular space,plasma membrane,cell surface,extracellular matrix,anchored component of membrane,very-low-density lipoprotein particle,chylomicron,extracellular exosome, |
| Protein Function | catalytic activity:Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.,disease:Defects in LPL are a cause of familial chylomicronemia [MIM:238600]; also known as hyperlipoproteinemia type I. Familial chylomicronemia is a recessive disorder usually manifesting in childhood. On a normal diet, patients often present with abdominal pain, hepatosplenomegaly, lipemia retinalis, eruptive xanthomata, and massive hypertriglyceridemia, sometimes complicated with acute pancreatitis.,disease:Defects in LPL are the cause of lipoprotein lipase deficiency (LPL deficiency) [MIM:238600]. LPL deficiency leads to hypertriglyceridemia.,function:The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). The enzyme functions in the presence of apolipoprotein C-2 on the luminal surface of vascular endothelium.,online information:Lipoprotein lipase entry,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the AB hydrolase superfamily. Lipase family.,similarity:Contains 1 PLAT domain.,subunit:Homodimer. Interacts with apolipoprotein C-2. Interacts with GPIHBP1., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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