ITM0420
ITM0420
ITM0420
from
$556.00
Price in reward points: 556
- Catalog: ITM0420
- Gene/Protein: LPL
- Product Description: Immunotag™ LPL Monoclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein LPL Clonality Monoclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. Concentration 1 mg/ml Reactive Species Human Host Species Mouse Immunogen Purified recombinant fragment of LPL expressed in E. Coli. Specificity LPL Monoclonal Antibody detects endogenous levels of LPL protein. Purification Affinity purification Form Ascitic fluid containing 0.03% sodium azide. Gene Name LPL Accession No. P06858 P11152 Alternate Names LPL; LIPD; Lipoprotein lipase; LPL Description lipoprotein lipase(LPL) Homo sapiens LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008], Cell Pathway/ Category Glycerolipid metabolism,PPAR,Alzheimer's disease, Protein Expression Adipose tissue,Brain,Milk,Placenta, Subcellular Localization extracellular region,extracellular space,plasma membrane,cell surface,extracellular matrix,anchored component of membrane,very-low-density lipoprotein particle,chylomicron,extracellular exosome, Protein Function catalytic activity:Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.,disease:Defects in LPL are a cause of familial chylomicronemia [MIM:238600]; also known as hyperlipoproteinemia type I. Familial chylomicronemia is a recessive disorder usually manifesting in childhood. On a normal diet, patients often present with abdominal pain, hepatosplenomegaly, lipemia retinalis, eruptive xanthomata, and massive hypertriglyceridemia, sometimes complicated with acute pancreatitis.,disease:Defects in LPL are the cause of lipoprotein lipase deficiency (LPL deficiency) [MIM:238600]. LPL deficiency leads to hypertriglyceridemia.,function:The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). The enzyme functions in the presence of apolipoprotein C-2 on the luminal surface of vascular endothelium.,online information:Lipoprotein lipase entry,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the AB hydrolase superfamily. Lipase family.,similarity:Contains 1 PLAT domain.,subunit:Homodimer. Interacts with apolipoprotein C-2. Interacts with GPIHBP1., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | LPL |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Purified recombinant fragment of LPL expressed in E. Coli. |
| Specificity | LPL Monoclonal Antibody detects endogenous levels of LPL protein. |
| Purification | Affinity purification |
| Form | Ascitic fluid containing 0.03% sodium azide. |
| Gene Name | LPL |
| Accession No. | P06858 P11152 |
| Alternate Names | LPL; LIPD; Lipoprotein lipase; LPL |
| Description | lipoprotein lipase(LPL) Homo sapiens LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Glycerolipid metabolism,PPAR,Alzheimer's disease, |
| Protein Expression | Adipose tissue,Brain,Milk,Placenta, |
| Subcellular Localization | extracellular region,extracellular space,plasma membrane,cell surface,extracellular matrix,anchored component of membrane,very-low-density lipoprotein particle,chylomicron,extracellular exosome, |
| Protein Function | catalytic activity:Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.,disease:Defects in LPL are a cause of familial chylomicronemia [MIM:238600]; also known as hyperlipoproteinemia type I. Familial chylomicronemia is a recessive disorder usually manifesting in childhood. On a normal diet, patients often present with abdominal pain, hepatosplenomegaly, lipemia retinalis, eruptive xanthomata, and massive hypertriglyceridemia, sometimes complicated with acute pancreatitis.,disease:Defects in LPL are the cause of lipoprotein lipase deficiency (LPL deficiency) [MIM:238600]. LPL deficiency leads to hypertriglyceridemia.,function:The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). The enzyme functions in the presence of apolipoprotein C-2 on the luminal surface of vascular endothelium.,online information:Lipoprotein lipase entry,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the AB hydrolase superfamily. Lipase family.,similarity:Contains 1 PLAT domain.,subunit:Homodimer. Interacts with apolipoprotein C-2. Interacts with GPIHBP1., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |