ITM0425
ITM0425
- Catalog: ITM0425
- Gene/Protein: KARS
- Product Description: Immunotag™ LysRS Monoclonal Antibody
504.0000
Price in reward points: 504
| Antibody Specification | |
| Datasheet | 
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| Target Protein | LysRS |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Purified recombinant fragment of LysRS(aa90-174) expressed in E. Coli. |
| Specificity | LysRS Monoclonal Antibody detects endogenous levels of LysRS protein. |
| Purification | Affinity purification |
| Form | Ascitic fluid containing 0.03% sodium azide. |
| Gene Name | KARS |
| Accession No. | Q15046 Q99MN1 |
| Alternate Names | KARS; KIAA0070; Lysine--tRNA ligase; Lysyl-tRNA synthetase; LysRS |
| Description | lysyl-tRNA synthetase(KARS) Homo sapiens Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Aminoacyl-tRNA biosynthesis, |
| Protein Expression | Bone marrow,Brain,Cerebellum,Hepatoma,Placenta, |
| Subcellular Localization | extracellular region,nucleus,cytoplasm,mitochondrion,mitochondrial matrix,cytosol,plasma membrane,microtubule cytoskeleton,aminoacyl-tRNA synthetase multienzyme complex, |
| Protein Function | catalytic activity:ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).,similarity:Belongs to the class-II aminoacyl-tRNA synthetase family.,subunit:Homodimer (By similarity); also part of a multisubunit complex that groups tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu, Lys, Met and Pro., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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