ITM0434
ITM0434
- Catalog: ITM0434
- Gene/Protein: MAP3K2
- Product Description: Immunotag™ MEK Kinase-2 Monoclonal Antibody
504.0000
Price in reward points: 504
| Antibody Specification | |
| Datasheet | 
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| Target Protein | MEK Kinase-2 |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IF,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Purified recombinant fragment of human MEK Kinase-2 expressed in E. Coli. |
| Specificity | MEK Kinase-2 Monoclonal Antibody detects endogenous levels of MEK Kinase-2 protein. |
| Purification | Affinity purification |
| Form | Ascitic fluid containing 0.03% sodium azide. |
| Gene Name | MAP3K2 |
| Accession No. | Q9Y2U5 Q61083 |
| Alternate Names | MAP3K2; MAPKKK2; MEKK2; Mitogen-activated protein kinase kinase kinase 2; MAPK/ERK kinase kinase 2; MEK kinase 2; MEKK 2 |
| Description | mitogen-activated protein kinase kinase kinase 2(MAP3K2) Homo sapiens The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | SAPK_JNK, Regulation of Actin Dynamics, Cell Growth, Stem cell pathway, MAPK_ERK_Growth,MAPK_G_Protein, B Cell Receptor |
| Protein Expression | Brain,Platelet,T-cell,Teratocarcinoma,Whole embryo, |
| Subcellular Localization | nucleoplasm,cytoplasm,cytosol, |
| Protein Function | catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-524.,function:Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 OPR domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Upon EGF stimulation, translocates into the nucleus.,subunit:Binds both upstream activators and downstream substrates in multimolecular complexes., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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