ITM0458
ITM0458
- Catalog: ITM0458
- Gene/Protein: MYL2
- Product Description: Immunotag™ MYL2 Monoclonal Antibody
504.0000
Price in reward points: 504
| Antibody Specification | |
| Datasheet | 
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| Target Protein | MYL2 |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Purified recombinant fragment of MYL2 expressed in E. Coli. |
| Specificity | MYL2 Monoclonal Antibody detects endogenous levels of MYL2 protein. |
| Purification | Affinity purification |
| Form | Ascitic fluid containing 0.03% sodium azide. |
| Gene Name | MYL2 |
| Accession No. | P10916 P51667 |
| Alternate Names | MYL2; Myosin regulatory light chain 2; ventricular/cardiac muscle isoform; MLC-2; MLC-2v |
| Description | myosin light chain 2(MYL2) Homo sapiens Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Cardiac muscle contraction,Focal adhesion,Tight junction,Leukocyte transendothelial migration,Regulates Actin and Cytoskeleton,Hypertrophic cardiomyopathy (HCM),Dilated cardiomyopathy, |
| Protein Expression | Cardiac ventricular muscle,Heart,Muscle,Prostate,Skeletal muscle,Striated muscle, |
| Subcellular Localization | cytosol,cytoskeleton,actin cytoskeleton,myosin complex,myofibril,sarcomere,A band, |
| Protein Function | disease:Defects in MYL2 are the cause of cardiomyopathy familial hypertrophic type 10 (CMH10) [MIM:608758]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.,disease:Defects in MYL2 are the cause of cardiomyopathy hypertrophic with mid-left ventricular chamber type 2 (MVC2) [MIM:608758]. MVC2 is a very rare variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening.,miscellaneous:This chain binds calcium.,similarity:Contains 3 EF-hand domains.,subunit:Myosin is an hexamer of 2 heavy chains and 4 light chains., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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