ITM0563
ITM0563
- Catalog: ITM0563
- Gene/Protein: ROR1
- Product Description: Immunotag™ ROR1 Monoclonal Antibody
504.0000
Price in reward points: 504
| Antibody Specification | |
| Datasheet | 
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| Target Protein | ROR1 |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IF,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Recombinant extracellular fragment of human ROR1 (aa30-406) fused with hIgGFc tag, expressed in HEK293 cells |
| Specificity | ROR1 Monoclonal Antibody detects endogenous levels of ROR1 protein. |
| Purification | Affinity purification |
| Form | Ascitic fluid containing 0.03% sodium azide. |
| Gene Name | ROR1 |
| Accession No. | Q01973 Q9Z139 |
| Alternate Names | ROR1; NTRKR1; Tyrosine-protein kinase transmembrane receptor ROR1; Neurotrophic tyrosine kinase; receptor-related 1 |
| Description | receptor tyrosine kinase like orphan receptor 1(ROR1) Homo sapiens This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012], |
| Protein Expression | Brain, |
| Subcellular Localization | cytoplasm,plasma membrane,integral component of plasma membrane,integral component of membrane,receptor complex, |
| Protein Function | catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,developmental stage:Expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues.,function:Tyrosine-protein kinase receptor whose role is not yet clear.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.,similarity:Contains 1 FZ (frizzled) domain.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 kringle domain.,similarity:Contains 1 protein kinase domain.,tissue specificity:Expressed strongly in human heart, lung, and kidney, but weakly in the CNS. The short isoform is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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