ITM0585
ITM0585
- Catalog: ITM0585
- Gene/Protein: SMAD6
- Product Description: Immunotag™ Smad6 Monoclonal Antibody
504.0000
Price in reward points: 504
| Antibody Specification | |
| Datasheet | 
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| Target Protein | SMAD6 |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Purified recombinant fragment of human Smad6 expressed in E. Coli. |
| Specificity | Smad6 Monoclonal Antibody detects endogenous levels of Smad6 protein. |
| Purification | Affinity purification |
| Form | Ascitic fluid containing 0.03% sodium azide. |
| Gene Name | SMAD6 |
| Accession No. | O43541 O35182 |
| Alternate Names | SMAD6; MADH6; Mothers against decapentaplegic homolog 6; MAD homolog 6; Mothers against DPP homolog 6; SMAD family member 6; SMAD 6; Smad6; hSMAD6 |
| Description | SMAD family member 6(SMAD6) Homo sapiens The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants have been found for this gene.[provided by RefSeq, Sep 2014], |
| Cell Pathway/ Category | TGF-beta, |
| Protein Expression | Brain,Placenta,Prostatic carcinoma,T-cell,Uterus, |
| Subcellular Localization | nucleus,transcription factor complex,cytoplasm,cytosol,integral component of membrane,protein complex, |
| Protein Function | function:Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions.,PTM:Phosphorylated by BMP type 1 receptor kinase and by PRKX.,similarity:Belongs to the dwarfin/SMAD family.,similarity:Contains 1 MH1 (MAD homology 1) domain.,similarity:Contains 1 MH2 (MAD homology 2) domain.,subunit:Interacts with NEDD4L (By similarity). Interacts with RNF111 and AXIN1. Interacts with TGF-beta type I receptor superfamily members, SMAD1, HOXC8 and HOXC9. Interacts with STAMBP and PRKX.,tissue specificity:Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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