ITM0595
ITM0595
- Catalog: ITM0595
- Gene/Protein: SRA1
- Product Description: Immunotag™ SRA1 Monoclonal Antibody
504.0000
Price in reward points: 504
| Antibody Specification | |
| Datasheet | 
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| Target Protein | SRA1 |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Purified recombinant fragment of SRA1 expressed in E. Coli. |
| Specificity | SRA1 Monoclonal Antibody detects endogenous levels of SRA1 protein. |
| Purification | Affinity purification |
| Form | Ascitic fluid containing 0.03% sodium azide. |
| Gene Name | SRA1 |
| Accession No. | Q9HD15 Q80VJ2 |
| Alternate Names | SRA1; PP7684; Steroid receptor RNA activator 1; Steroid receptor RNA activator protein; SRAP |
| Description | steroid receptor RNA activator 1(SRA1) Homo sapiens Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA. [provided by RefSeq, Mar 2012], |
| Protein Expression | Brain,Lymph,Mammary gland, |
| Subcellular Localization | nucleus,nucleoplasm,cytoplasm,plasma membrane,microtubule cytoskeleton,intracellular ribonucleoprotein complex,intercellular bridge, |
| Protein Function | function:Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.,miscellaneous:Appears to be the first example of a new class of functional RNAs also able to encode a protein.,similarity:Belongs to the SRA1 family.,subunit:SRA1 RNA exists in a ribonucleoprotein complex containing NCOA1. The RNA also forms a complex with PUS1 and RARG in the nucleus. Interacts with AR.,tissue specificity:Highly expressed in liver and skeletal muscle and to a lesser extent in brain. Also expressed in both normal and tumorigenic breast epithelial cell lines. Significantly up-regulated in human tumors of the breast, ovary, and uterus., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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