ITM0644
ITM0644
- Catalog: ITM0644
- Gene/Protein: VCAM1
- Product Description: Immunotag™ VCAM-1 Monoclonal Antibody
504.0000
Price in reward points: 504
| Antibody Specification | |
| Datasheet | 
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| Target Protein | VCAM-1 |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Purified recombinant fragment of human VCAM-1 expressed in E. Coli. |
| Specificity | VCAM-1 Monoclonal Antibody detects endogenous levels of VCAM-1 protein. |
| Purification | Affinity purification |
| Form | Ascitic fluid containing 0.03% sodium azide. |
| Gene Name | VCAM1 |
| Accession No. | P19320 P29533 |
| Alternate Names | VCAM1; L1CAM; Vascular cell adhesion protein 1; V-CAM 1; VCAM-1; INCAM-100; CD antigen CD106 |
| Description | vascular cell adhesion molecule 1(VCAM1) Homo sapiens This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010], |
| Cell Pathway/ Category | Cell adhesion molecules (CAMs),Leukocyte transendothelial migration, |
| Protein Expression | Endothelial cell,Liver,Plasma,Retinal pigment epithelium,Synovial m |
| Subcellular Localization | podosome,extracellular space,early endosome,endoplasmic reticulum,Golgi apparatus,plasma membrane,microvillus,external side of plasma membrane,cell surface,membrane,integral component of membrane,filopodium, |
| Protein Function | Additional isoforms seem to exist,disease:May play an important role in the genesis of atherosclerosis and rheumatoid arthritis.,domain:Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.,function:Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.,induction:By cytokines (e.g. IL-1, TNF-alpha).,online information:VCAM-1,online information:VCAM1 entry,PTM:Sialoglycoprotein.,similarity:Contains 7 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Binds to ECMV-D capsid proteins and acts as a receptor for this virus.,tissue specificity:Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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