ITM1012
ITM1012
- Catalog: ITM1012
- Gene/Protein: ARRB2
- Product Description: Immunotag™ Arrestin-β-2 Monoclonal Antibody
504.0000
Price in reward points: 504
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Arrestin-β-2 |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IF |
| Recommended Dilution | Western Blot: 1/1000 - 1/2000. Immunofluorescence: 1/100 - 1/500. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat,Pig |
| Host Species | Mouse |
| Immunogen | Purified recombinant human Arrestin-β-2 (C-terminus) protein fragments expressed in Ecoli |
| Specificity | Arrestin-β-2 Monoclonal Antibody detects endogenous levels of Arrestin-β-2 protein. |
| Purification | Affinity purification |
| Form | Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol. |
| Gene Name | ARRB2 |
| Accession No. | P32121 Q91YI4 P29067 |
| Alternate Names | ARRB2; ARB2; ARR2; Beta-arrestin-2; Arrestin beta-2 |
| Description | arrestin beta 2(ARRB2) Homo sapiens Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012], |
| Cell Pathway/ Category | MAPK_ERK_Growth,MAPK_G_Protein,Chemokine,Endocytosis,Olfactory transduction, |
| Protein Expression | Brain,Cord blood,Endometrium,Muscle,Pancreas,Testis,Thyroid, |
| Subcellular Localization | nucleus,cytoplasm,cytosol,plasma membrane,clathrin-coated pit,postsynaptic density,basolateral plasma membrane,endocytic vesicle,cytoplasmic vesicle,dendritic spine,postsynaptic membrane, |
| Protein Function | function:Regulates beta-adrenergic receptor function. Beta-arrestins seem to bind phosphorylated beta-adrenergic receptors, thereby causing a significant impairment of their capacity to activate G(S) proteins.,online information:Arrestin entry,similarity:Belongs to the arrestin family., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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