ITM1044
ITM1044
- Catalog: ITM1044
- Gene/Protein: HNRNPU
- Product Description: Immunotag™ hnRNP U Monoclonal Antibody
504.0000
Price in reward points: 504
| Antibody Specification | |
| Datasheet | 
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| Target Protein | hnRNP U |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB |
| Recommended Dilution | Western Blot: 1/1000 - 1/2000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Bovine,Pig,Rb |
| Host Species | Mouse |
| Immunogen | Purified recombinant human hnRNP U protein fragments expressed in E.coli. |
| Specificity | hnRNP U Monoclonal Antibody detects endogenous levels of hnRNP U protein. |
| Purification | Affinity purification |
| Form | Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol. |
| Gene Name | HNRNPU |
| Accession No. | Q00839 Q8VEK3 |
| Alternate Names | HNRNPU; HNRPU; SAFA; U21.1; Heterogeneous nuclear ribonucleoprotein U; hnRNP U; Scaffold attachment factor A; SAF-A; p120; pp120 |
| Description | heterogeneous nuclear ribonucleoprotein U(HNRNPU) Homo sapiens This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the |
| Cell Pathway/ Category | Spliceosome, |
| Protein Expression | Colon,Epithelium,Eye,Liver,Lymph,Ovarian carcinoma,Placenta |
| Subcellular Localization | nucleus,nucleoplasm,telomerase holoenzyme complex,cell surface,membrane,intracellular ribonucleoprotein complex,extracellular matrix,cytoplasmic ribonucleoprotein granule,CRD-mediated mRNA stability complex,catalytic step 2 sp |
| Protein Function | function:Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Bind to double- and single-stranded DNA and RNA.,PTM:Arg-732 and Arg-738 are dimethylated, probably to asymmetric dimethylarginine.,PTM:Extensively phosphorylated.,similarity:Contains 1 B30.2/SPRY domain.,similarity:Contains 1 SAP domain.,subcellular location:Component of ribonucleosomes. Also found associated with the cell surface.,subunit:Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRNPA1, HNRNPA2B1, HNRPA3, HNRNPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRNPR, HNRNPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8. Ligand for CR2., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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