ITM1046
ITM1046
- Catalog: ITM1046
- Gene/Protein: CBX1
- Product Description: Immunotag™ HP1β Monoclonal Antibody
504.0000
Price in reward points: 504
| Antibody Specification | |
| Datasheet | 
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| Target Protein | HP1β |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB |
| Recommended Dilution | Western Blot: 1/1000 - 1/2000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat,Bovine,Chicken,Dog,Pig |
| Host Species | Mouse |
| Immunogen | Purified recombinant human HP1β protein fragments expressed in E.coli. |
| Specificity | HP1β Monoclonal Antibody detects endogenous levels of HP1β protein. |
| Purification | Affinity purification |
| Form | Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol. |
| Gene Name | CBX1 |
| Accession No. | P83916 P83917 |
| Alternate Names | CBX1; CBX; Chromobox protein homolog 1; HP1Hsbeta; Heterochromatin protein 1 homolog beta; HP1 beta; Heterochromatin protein p25; M31; Modifier 1 protein; p25beta |
| Description | chromobox 1(CBX1) Homo sapiens This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008], |
| Protein Expression | Brain,Cajal-Retzius cell,Epithelium,Fetal brain cortex,Liver,Liver tumor,Ovary, |
| Subcellular Localization | chromosome, centromeric region,nuclear chromosome, telomeric region,chromatin,female pronucleus,male pronucleus,nucleus,nucleoplasm,nuclear heterochromatin,pericentric heterochromatin,spindle,chromocenter, |
| Protein Function | function:Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.,online information:Heterochromatin protein 1 entry,PTM:Not phosphorylated.,similarity:Contains 2 chromo domains.,subcellular location:Unassociated with chromosomes during mitosis.,subunit:Homodimer. Interacts directly with CHAF1A, EMSY, LBR, TIF1/TIF1A and TRIM28/TIF1B PXVXL motif via the chromoshadow domain. Interacts directly with histone H3 methylated at 'Lys-9' via the chromo domain. Interacts with SUV39H1 and SETDB1, SUV420H1 and SUV420H2. Interacts with PRDM6.,tissue specificity:In all adult and embryonic tissues., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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