ITM1100
ITM1100
- Catalog: ITM1100
- Gene/Protein: SDCBP
- Product Description: Immunotag™ Syntenin-1 Monoclonal Antibody
504.0000
Price in reward points: 504
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Antibody Specification | |
Datasheet | |
Target Protein | Syntenin-1 |
Clonality | Monoclonal |
Storage/Stability | -20°C/1 year |
Application | WB |
Recommended Dilution | Western Blot: 1/1000 - 1/2000. Not yet tested in other applications. |
Concentration | 1 mg/ml |
Reactive Species | Human,Rat,Dog,Pig |
Host Species | Mouse |
Immunogen | Purified recombinant human Syntenin-1 protein fragments expressed in Ecoli |
Specificity | Syntenin-1 Monoclonal Antibody detects endogenous levels of Syntenin-1 protein. |
Purification | Affinity purification |
Form | Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol. |
Gene Name | SDCBP |
Accession No. | O00560 O08992 Q9JI92 |
Alternate Names | SDCBP; MDA9; SYCL; Syntenin-1; Melanoma differentiation-associated protein 9; MDA-9; Pro-TGF-alpha cytoplasmic domain-interacting protein 18; TACIP18; Scaffold protein Pbp1; Syndecan-binding protein 1 |
Description | syndecan binding protein(SDCBP) Homo sapiens The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008], |
Protein Expression | Bladder,Brain,Pre-B cell, |
Subcellular Localization | extracellular space,intracellular,nucleus,cytoplasm,endoplasmic reticulum membrane,cytosol,cytoskeleton,plasma membrane,interleukin-5 receptor complex,adherens junction,cell-cell adherens junction,focal adhesion,membr |
Protein Function | function:Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.,induction:By gamma interferon in melanoma cells.,PTM:Phosphorylated on tyrosine residues.,similarity:Contains 2 PDZ (DHR) domains.,subcellular location:Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Monomer and homodimer (By similarity). Interacts with SDC1, SDC2, SDC3, SDC4, NRXN2, EPHA7, EPHB1, NF2 isoform 1, TGFA and IL5RA. Interacts with neurofascin, SDCBP2 and PTPRJ.,tissue specificity:Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest expression in heart and placenta., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |