ITM1201
ITM1201
- Catalog: ITM1201
- Gene/Protein: kdm5c
- Product Description: Immunotag™ KDM5C/Jarid1C/SMCX mouse mAb
405.0000
Price in reward points: 405
| Antibody Specification | |
| Datasheet | 
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| Target Protein | KDM5C/Jarid1C/SMCX |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ICC |
| Recommended Dilution | wb 1:1000 icc 1:150 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Purified recombinant human KDM5C / Jarid1C / SMCX protein fragments expressed in E.coli |
| Specificity | This antibody detects endogenous levels of KDM5C / Jarid1C / SMCX and does not corss-react with related proteins |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | kdm5c |
| Accession No. | P41229 P41230 |
| Alternate Names | DXS1272E;Histone demethylase JARID1C;JARID1C;JmjC domain containing protein SMCX;Jumonji AT rich interactive domain 1C;Jumonji, AT rich interactive domain 1C (RBP2 like); Jumonji/ARID domain-containing protein 1C;KDM5C;KDM5C_HUMAN;Lysine (K) specific demethylase 5C;Lysine-specific demethylase 5C;MRXJ;MRXSCJ;MRXSJ;Protein SmcX;Protein Xe169;rbp2 like protein;Selected cDNA on X;SMCX;Smcx homolog X chromosome;SmcX protein; SmcX protein;Smcy homolog X linked;XE169;Xe169 protein;Xe169 protein. |
| Description | lysine demethylase 5C(KDM5C) Homo sapiens This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009], |
| Protein Expression | Blood,Epithelium,Eye,Fibroblast,Uterus, |
| Subcellular Localization | nucleus,nucleoplasm, |
| Protein Function | cofactor:Alpha-ketoglutarate.,cofactor:Fe(2+).,disease:Defects in KDM5C are a cause of X-linked mental retardation (XLMR) [MIM:300534]. Mental retardation is usually defined as cognitive impairment with an IQ less than 70. Etiologically, mental retardation is a very heterogeneous condition that involves environmental, stochastic and/or genetic factors.,domain:Both the JmjC domain and the JmjN domain are required for enzymatic activity.,domain:The first PHD-type zinc finger domain recognizes and binds H3-K9Me3.,function:Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements.,miscellaneous:Escapes X-inactivation.,similarity:Belongs to the JARID1 histone demethylase family.,similarity:Contains 1 ARID domain.,similarity:Contains 1 JmjC domain.,similarity:Contains 1 JmjN domain.,similarity:Contains 2 PHD-type zinc fingers.,subunit:Part of two distinct complexes, one containing E2F6, and the other containing REST.,tissue specificity:Expressed in all tissues examined. Highest levels found in brain and skeletal muscle., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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