ITM1210
ITM1210
- Catalog: ITM1210
- Gene/Protein: dctn1
- Product Description: Immunotag™ Dynactin 1(N-term) mouse mAb
405.0000
Price in reward points: 405
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Dynactin 1 (N-term) |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IP |
| Recommended Dilution | wb 1:500 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Purified recombinant Dynactin 1 protein fragments expressed in E.coli |
| Specificity | This antibody detects endogenous levels of Dynactin 1(N-terminus),and does not cross-react with related proteins. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | dctn1 |
| Accession No. | Q14203 O08788 |
| Alternate Names | 150 kDa dynein associated polypeptide;150 kDa dynein-associated polypeptide;DAP 150;DAP-150;DAP150;DCTN 1;DCTN1;DCTN1_HUMAN;DP 150;DP-150;DP150;Dynactin 1 (p150 Glued (Drosophila) homolog);dynactin 1 (p150 glued homolog Drosophila);Dynactin 1;Dynactin subunit 1;Dynactin1;HMN7B;p135;p150 Glued (Drosophila) homolog;p150 glued;p150 glued homolog;p150(GLUED) DROSOPHILA HOMOLOG OF;p150-glued;p150glued. |
| Description | dynactin subunit 1(DCTN1) Homo sapiens This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [ |
| Cell Pathway/ Category | Huntington's disease, |
| Protein Expression | Amygdala,Brain,Cervix,Endometrium,Heart,Lung,Spleen, |
| Subcellular Localization | kinetochore,spindle pole,nuclear envelope,cytoplasm,centrosome,centriole,spindle,cytosol,dynactin complex,microtubule,membrane,dynein complex,retromer complex,cell leading edge,microtubule plus-e |
| Protein Function | disease:Defects in DCTN1 are the cause of progressive lower motor neuron disease (PLMND) [MIM:607641]. PLMND is a progressive dominant disease that has no sensory symptoms.,function:Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.,PTM:Phosphorylated.,similarity:Belongs to the dynactin 150 kDa subunit family.,similarity:Contains 1 CAP-Gly domain.,subunit:Large macromolecular complex of at least 10 components; p150(glued) binds directly to microtubules and to cytoplasmic dynein. Interacts with the C-terminus of MAPRE1, MAPRE2 and MAPRE3.,tissue specificity:Brain., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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