ITM1237
ITM1237
- Catalog: ITM1237
- Gene/Protein: mpi
- Product Description: Immunotag™ Mannose Phosphate Isomerase mouse mAb
405.0000
Price in reward points: 405
| Antibody Specification | |
| Datasheet | 
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| Target Protein | MPI |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ICC |
| Recommended Dilution | wb 1:1000 icc 1:300 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat |
| Host Species | Mouse |
| Immunogen | Purified recombinant human Mannose Phosphate Isomerase protein fragments expressed in E.coli. |
| Specificity | This antibody detects endogenous levels of Mannose Phosphate Isomerase and does not cross-react with related proteins. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | mpi |
| Accession No. | P34949 Q924M7 |
| Alternate Names | PMI1;CDG1B;FLJ39201;Mannose 6 phosphate isomerase;Mannose-6-phosphate isomerase; MANNOSEPHOSPHATE ISOMERASE;MGC94106;MPI;MPI_HUMAN;Phosphohexomutase;phosphomannose isomerase 1;Phosphomannose isomerase;PMI;PMI1. |
| Description | mannose phosphate isomerase(MPI) Homo sapiens Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014], |
| Cell Pathway/ Category | Fructose and mannose metabolism,Amino sugar and nucleotide sugar metabolism, |
| Protein Expression | Blood,Brain,Placenta,Testis, |
| Subcellular Localization | cytoplasm,cytosol,extracellular exosome, |
| Protein Function | catalytic activity:D-mannose 6-phosphate = D-fructose 6-phosphate.,cofactor:Binds 1 zinc ion per subunit.,disease:Defects in MPI are the cause of congenital disorder of glycosylation type 1B (CDG1B) [MIM:602579]; also known as carbohydrate-deficient glycoprotein syndrome type Ib (CDGS1B). Congenital disorders of glycosylation are metabolic deficiencies in glycoprotein biosynthesis that usually cause severe mental and psychomotor retardation. They are characterized by under-glycosylated serum glycoproteins. CDG1B is clinically characterized by protein-losing enteropathy.,function:Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.,pathway:Nucleotide-sugar biosynthesis; GDP-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.,similarity:Belongs to the mannose-6-phosphate isomerase type 1 family.,tissue specificity:Expressed in all tissues, but more abundant in heart, brain and skeletal muscle., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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