ITM1238
ITM1238
- Catalog: ITM1238
- Gene/Protein: krt7
- Product Description: Immunotag™ Keratin 7(C-term) mouse mAb
405.0000
Price in reward points: 405
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Keratin 7 (C-term) |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ICC |
| Recommended Dilution | wb 1:1000 icc 1:150 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Purified recombinant human Keratin 7 protein fragments expressed in E.coli. |
| Specificity | This antibody detects endogenous levels of Keratin 7 and does not cross-react with related proteins. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | krt7 |
| Accession No. | P08729 Q9DCV7 |
| Alternate Names | CK 7;CK-7;ck7;Cytokeratin 7;Cytokeratin-7;Cytokeratin7;D15Wsu77e;K2C7;K2C7_HUMAN;K7;Keratin 55k type ii cytoskeletal;Keratin 7;Keratin simple epithelial type 1 k7;Keratin type II cytoskeletal 7;Keratin type ii cytoskletal 7;Keratin, 55K type II cytoskeletal;Keratin,simple epithelial;Keratin,simple epithelial type I,K7;Keratin,type II cytoskeletal 7;Keratin-7;Keratin7;KRT 7;Krt2-7;KRT7;MGC11625;MGC129731;mgc3625;Sarcolectin;SCL;Type ii mesothelial keratin k7;Type-II keratin Kb7. |
| Description | keratin 7(KRT7) Homo sapiens The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008], |
| Protein Expression | Colon carcinoma,Epithelium,Keratinocyte,Mammary cancer,Mesothelium,Ovarian carcinoma,Pancreas,PCR r |
| Subcellular Localization | nucleus,cytoplasm,intermediate filament,keratin filament,extracellular exosome, |
| Protein Function | function:Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).,induction:Up-regulated by retinoic acid.,mass spectrometry: PubMed:11840567,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,PTM:Arg-20 is dimethylated, probably to asymmetric dimethylarginine.,similarity:Belongs to the intermediate filament family.,subunit:Heterotetramer of two type I and two type II keratins. Interacts with eukaryotic translation initiator factor 3 (eIF3) subunit EIF3S10 and with HPV16 E7.,tissue specificity:Expressed in cultured epidermal, bronchial and mesothelial cells but absent in colon, ectocervix and liver. Observed throughout the glandular cells in the junction between stomach and esophagus but is absent in the esophagus., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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