ITM1257
ITM1257
- Catalog: ITM1257
- Gene/Protein: icam1
- Product Description: Immunotag™ CD54(ICAM-1) mouse mAb
405.0000
Price in reward points: 405
| Antibody Specification | |
| Datasheet | 
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| Target Protein | CD54 (ICAM1) |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB |
| Recommended Dilution | wb 1:1000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Purified recombinant human CD54(ICAM-1) protein fragments expressed in E.coli. |
| Specificity | This antibody detects endogenous levels of CD54(ICAM-1) and does not cross-react with related proteins. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | icam1 |
| Accession No. | P05362 P13597 |
| Alternate Names | Antigen identified by monoclonal;BB2;BB 2;BB2;CD 54;CD_antigen=CD54;CD54;CD54 antigen; Cell surface glycoprotein P3.58;Human rhinovirus receptor;ICAM 1;ICAM-1;ICAM1; ICAM1_HUMAN;Intercellular adhesion molecule 1;intercellular adhesion molecule 1 (CD54), human rhinovirus receptor;Major group rhinovirus receptor;MALA 2;MALA2;MyD 10;MyD10; P3.58;Surface antigen of activated B cells;Surface antigen of activated B cells, BB2. |
| Description | intercellular adhesion molecule 1(ICAM1) Homo sapiens This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Cell adhesion molecules (CAMs),Natural killer cell mediated cytotoxicity,Leukocyte transendothelial migration,Viral myocarditis, |
| Protein Expression | Blood,Kidney,Liver,Melanoma,Plasma, |
| Subcellular Localization | immunological synapse,extracellular space,plasma membrane,integral component of plasma membrane,focal adhesion,external side of plasma membrane,cell surface,membrane,integral component of membrane,membrane raft,extracellula |
| Protein Function | function:ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.,online information:ICAM-1,online information:Icosahedral capsid structure,online information:Intercellular adhesion molecule entry,polymorphism:Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria.,PTM:Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.,similarity:Belongs to the immunoglobulin superfamily. ICAM family.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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