ITM1300
ITM1300
- Catalog: ITM1300
- Gene/Protein: safb-1
- Product Description: Immunotag™ SAFB1 mouse mAb
405.0000
Price in reward points: 405
| Antibody Specification | |
| Datasheet | 
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| Target Protein | SAF-B1 |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ICC |
| Recommended Dilution | wb 1:1000 icc 1:200 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Purified recombinant human SAFB1 protein fragments expressed in E.coli. |
| Specificity | This antibody detects endogenous levels of SAFB1 and does not cross-react with related prote |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | safb-1 |
| Accession No. | Q15424 D3YXK2 |
| Alternate Names | DKFZp779C1727;glutathione S transferase fusion protein;HAP;HET;HSP27 ERE TATA binding protein;HSP27 ERE-TATA-binding protein;HSP27 estrogen response element-TATA box-binding protein;SAF B;SAF-B1;SAFB 1;SAFB;SAFB1;SAFB1_HUMAN;scaffold attachment factor B1. |
| Description | scaffold attachment factor B(SAFB) Homo sapiens This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript v |
| Protein Expression | Brain,Cervix carcinoma,Epithelium,Liver,Mammary carcinoma, |
| Subcellular Localization | nucleus,nucleoplasm, |
| Protein Function | function:Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (By similarity). Can function as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription. Can inhibit cell proliferation.,similarity:Contains 1 RRM (RNA recognition motif) domain.,similarity:Contains 1 SAP domain.,subunit:Monomer. Can form homodimers. Interacts with KHDRBS3, POLR2A, SAFB2 or SFRS1, SFRS9 and TRA2B/SFRS10.,tissue specificity:Ubiquitous. Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide number of breast cancer cell lines., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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