ITM1302
ITM1302
- Catalog: ITM1302
- Gene/Protein: tab1
- Product Description: Immunotag™ TAB1(N-term) mouse mAb
405.0000
Price in reward points: 405
| Antibody Specification | |
| Datasheet | 
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| Target Protein | TAB1 (N-term) |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB |
| Recommended Dilution | wb 1:1000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Purified recombinant human TAB1(N-terminus) protein fragments expressed in E.coli. |
| Specificity | This antibody detects endogenous levels of TAB1(N-terminus) and does not cross-react with related proteins. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | tab1 |
| Accession No. | Q15750 Q8CF89 |
| Alternate Names | 2310012M03Rik;3'-Tab1;MAP3K7IP 1;MAP3K7IP1;MGC57664;Mitogen activated protein kinase kinase kinase 7 interacting protein 1;Mitogen-activated protein kinase kinase kinase 7-interacting protein 1;TAB 1;TAB1;TAB1_HUMAN;TAK1 binding protein 1;TAK1-binding protein 1;TGF beta activated kinase 1 binding protein 1;TGF-beta activated kinase 1/MAP3K7 binding protein 1;TGF-beta-activated kinase 1 and MAP3K7-binding protein 1;TGF-beta-activated kinase 1-binding protein 1;Transforming growth factor beta activated kinase binding protein 1. |
| Description | TGF-beta activated kinase 1 (MAP3K7) binding protein 1(TAB1) Homo sapiens The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced tr |
| Cell Pathway/ Category | MAPK_ERK_Growth,MAPK_G_Protein,Toll_Like,NOD-like receptor, |
| Protein Expression | Brain,Caudate nucleus,Placenta,PNS, |
| Subcellular Localization | nucleoplasm,cytoplasm,cytosol,endosome membrane,protein complex, |
| Protein Function | function:May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.,similarity:Contains 1 PP2C-like domain.,subunit:Interacts with MAP3K7, XIAP and BIRC7.,tissue specificity:Ubiquitous., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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