ITM1324
ITM1324
- Catalog: ITM1324
- Gene/Protein: atic
- Product Description: Immunotag™ ATIC mouse mAb
405.0000
Price in reward points: 405
| Antibody Specification | |
| Datasheet | 
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| Target Protein | ATIC |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB |
| Recommended Dilution | wb 1:1000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Mouse |
| Immunogen | Purified recombinant human ATIC protein fragments expressed in E.coli. |
| Specificity | This antibody detects endogenous levels of ATIC and does not cross-react with related proteins. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | atic |
| Accession No. | P31939 Q9CWJ9 |
| Alternate Names | 5 aminoimidazole 4 carboxamide 1 beta D ribonucleotide transformylase/inosinicase;5 aminoimidazole 4 carboxamide ribonucleotide formyltransferase;5 aminoimidazole 4 carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase;5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase;AICAR;AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme;AICAR transformylase;AICARFT;AICARFT/IMPCHASE;ATIC; Bifunctional purine biosynthesis protein PURH;FLJ93545;IMP cyclohydrolase;IMP synthase;IMP synthetase;IMPCHASE;Inosinicase;OK/SW-cl.86; Phosphoribosylaminoimidazolecarboxamide formyltransferase; Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase;PUR9_HUMAN; PURH. |
| Description | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase(ATIC) Homo sapiens This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. [provided by RefSeq, Sep 2009], |
| Cell Pathway/ Category | Purine metabolism,One carbon pool by folate, |
| Protein Expression | Brain,Cajal-Retzius |
| Subcellular Localization | mitochondrion,cytosol,cell-cell adherens junction,membrane,extracellular exosome, |
| Protein Function | catalytic activity:10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.,catalytic activity:IMP + H(2)O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.,disease:Defects in ATIC are the cause of AICA-ribosuria [MIM:608688]; also known as AICA-ribosiduria. AICA-ribosuria is a neurologically devastating inborn error of purine biosynthesis. AICA-ribosuria patients excrete massive amounts of AICA-riboside in the urine and accumulate AICA-ribotide and its derivatives in erythrocytes and fibroblasts. AICA-ribosuria causes profound mental retardation, epilepsy, dysmorphic features and congenital blindness.,domain:The IMP cyclohydrolase activity resides in the N-terminal region.,pathway:Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.,pathway:Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.,similarity:Belongs to the purH family., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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