ITM1343
ITM1343
- Catalog: ITM1343
- Gene/Protein: birc3
- Product Description: Immunotag™ cIAP2 mouse mAb
405.0000
Price in reward points: 405
| Antibody Specification | |
| Datasheet | 
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| Target Protein | cIAP2 |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB |
| Recommended Dilution | wb 1:1000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Monkey |
| Host Species | Mouse |
| Immunogen | Purified recombinant human c-IAP2 protein fragments expressed in E.coli |
| Specificity | This antibody detects endogenous levels of c-IAP2 and does not cross-react with related proteins. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | birc3 |
| Accession No. | Q13489 O08863 |
| Alternate Names | AIP 1;AIP1;API 2;API2;API2;Apoptosis inhibitor 2;Baculoviral IAP repeat containing 3;Baculoviral IAP repeat containing protein 3;Baculoviral IAP repeat-containing protein 3;BIRC 3;BIRC3;BIRC3;BIRC3_HUMAN;C IAP2;C-IAP2;CIAP 2;CIAP 2;CIAP2;HAIP 1;HAIP1;HAIP1; HIAP 1;HIAP-1;HIAP1;IAP homolog C;IAP-1;Inhibitor of apoptosis protein 1;Inhibitor of apoptosis protein 1;MALT 2;MALT2;Mammalian IAP homolog C;MIHC;MIHC;RING finger protein 49;RNF49;TNFR2 TRAF signaling complex protein 1;TNFR2 TRAF signalling complex protein;TNFR2-TRAF-signaling complex protein 1. |
| Description | baculoviral IAP repeat containing 3(BIRC3) Homo sapiens This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011], |
| Cell Pathway/ Category | Ubiquitin mediated proteolysis,Apoptosis_Inhibition,Apoptosis_Mitochondrial,Apoptosis_Overview,Focal adhesion,NOD-like receptor,Pathways in cancer,Small cell lung cancer, |
| Protein Expression | Fetal liver,Liver,Lymph, |
| Subcellular Localization | nucleus,nucleoplasm,cytoplasm,cytosol,spindle microtubule,protein complex,membrane raft, |
| Protein Function | disease:A chromosomal aberration involving BIRC3 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with MALT1. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.,function:Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2).,similarity:Belongs to the IAP family.,similarity:Contains 1 CARD domain.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 3 BIR repeats.,subunit:Interacts with SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity.,tissue specificity:Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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