ITM1353
ITM1353
- Catalog: ITM1353
- Gene/Protein: chd4
- Product Description: Immunotag™ CHD4 mouse mAb
405.0000
Price in reward points: 405
| Antibody Specification | |
| Datasheet | 
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| Target Protein | CHD4 |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IP |
| Recommended Dilution | wb 1:1000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Purified recombinant human CHD4 protein fragments expressed in E.coli. |
| Specificity | This antibody detects endogenous levels of CHD4 and does not cross-react with related proteins. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | chd4 |
| Accession No. | Q14839 Q6PDQ2 |
| Alternate Names | ATP dependent helicase CHD4;ATP-dependent helicase CHD4;CHD 4;CHD-4;CHD4;CHD4_HUMAN; Chromodomain helicase DNA binding protein 4;Chromodomain-helicase-DNA-binding protein 4;DKFZp686E06161;Mi 2 autoantigen 218 kDa protein;Mi 2b;Mi-2 autoantigen 218 kDa protein;Mi2 beta;Mi2-beta. |
| Description | chromodomain helicase DNA binding protein 4(CHD4) Homo sapiens The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014], |
| Protein Expression | Epithelium,Pancreas,Skin,Uterus, |
| Subcellular Localization | nuclear chromatin,nucleus,nucleoplasm,cytoplasm,centrosome,membrane,NuRD complex,protein-DNA complex,protein complex, |
| Protein Function | disease:One of the main antigens reacting with anti-MI-2 positive sera of dermatomyositis.,function:Probable transcription regulator.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the SNF2/RAD54 helicase family.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,similarity:Contains 2 chromo domains.,similarity:Contains 2 PHD-type zinc fingers.,subunit:Central component of the nucleosome remodeling and histone deacetylase (NuRD) repressor complex. Interacts with TRIM27. Part of a complex containing ATR and HDAC2. Interacts with KLF1; the interaction depends on sumoylation of KLF1, and leads to its transcriptional repression., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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