ITM1355
ITM1355
- Catalog: ITM1355
- Gene/Protein: lin28a
- Product Description: Immunotag™ LIN28A mouse mAb
405.0000
Price in reward points: 405
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | LIN28A |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB |
| Recommended Dilution | wb 1:1000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Mouse |
| Immunogen | Purified recombinant human LIN28A protein fragments expressed in E.coli |
| Specificity | This antibody detects endogenous levels of LIN28A and does not cross-react with related proteins. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | lin28a |
| Accession No. | Q9H9Z2 Q8K3Y3 |
| Alternate Names | CSDD1;FLJ12457;LIN 28;Lin-28A;LIN28;LIN28A;LN28A_HUMAN;Protein lin-28 homolog A;ZCCHC1; Zinc finger CCHC domain-containing protein 1. |
| Description | lin-28 homolog A(LIN28A) Homo sapiens This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of microRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with cancer progression in multiple tissues. [provided by RefSeq, Sep 2015], |
| Protein Expression | Placenta,Teratocarcinoma, |
| Subcellular Localization | cytoplasmic mRNA processing body,nucleus,nucleolus,cytoplasm,rough endoplasmic reticulum,cytosol,cytoplasmic stress granule, |
| Protein Function | developmental stage:Expressed in fetal liver. Expression decreases during differentiation of ES cells or upon induction of neuronal differentiation by retinoic acid.,domain:The CSD domain is required for function in muscle differentiation.,function:Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression.,induction:Can be negatively regulated by the interaction of microRNAs miR-125a and miR-125b with at least two miRNA responsive elements (miREs) in the 3'-UTR of this gene. These interactions may reduce both translation efficiency and mRNA abundance. Negatively regulated by retinoic acid.,similarity:Belongs to the lin-28 family.,similarity:Contains 1 CSD (cold-shock) domain.,similarity:Contains 2 CCHC-type zinc fingers.,subcellular location:Nucleolar localization observed in 10 - 15% of the nuclei in differentiated myotubes.,subunit:During skeletal muscle differentiation, associated with translation initiation complexes in the polysomal compartment. Directly interacts with EIF3S2. Interaction with NCL is RNA-dependent.,tissue specificity:Expressed in embryonic stem cells (ES cells), placenta and testis., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
| English_US |
|
| Danish |
|
| Dutch |
|
| English_UK |
|
| French |
|
| German |
|
| Spanish |
|
| Norwegian |
|
| Portuguese |
|
| Finnish |
|
| Swedish |
|
| Polish |
|