ITM1359
ITM1359
- Catalog: ITM1359
- Gene/Protein: dr5
- Product Description: Immunotag™ DR5 mouse mAb
405.0000
Price in reward points: 405
| Antibody Specification | |
| Datasheet | 
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| Target Protein | DR5 |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB |
| Recommended Dilution | wb 1:2000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Purified recombinant human DR5 protein fragments expressed in E.coli. |
| Specificity | This antibody detects endogenous levels of DR5 and does not cross-react with related proteins. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | dr5 |
| Accession No. | O14763 Q9QZM4 |
| Alternate Names | Fas like protein ;Apoptosis inducing protein TRICK2A/2B ;Apoptosis inducing receptor TRAIL R2 ;CD 262 ;CD262 ;CD262 antigen ;Cytotoxic TRAIL receptor 2 ;Death domain containing receptor for TRAIL/Apo 2L ;Death domain containing receptor for TRAIL/Apo2L ;Death receptor 5 ;DR 5 ;DR5 ;Fas like protein precursor ;KILLER ;KILLER/DR5 ;OTTHUMP00000123492 ;OTTHUMP00000123493 ;p53 regulated DNA damage inducible cell death receptor (killer) ;p53 regulated DNA damage inducible cell death receptor(killer) ;TNF related apoptosis inducing ligand receptor 2 ;TNF related apoptosis inducing ligand receptor 2 ;TNF-related apoptosis-inducing ligand receptor 2 ;TNFRSF10B ;TR10B_HUMAN ;TRAIL R2 ;TRAIL receptor 2 ;TRAIL-R2 ;TRAILR2 ;TRANCER ;TRICK2 ;TRICK2A ;TRICK2B ;TRICKB ;Tumor necrosis factor receptor like protein ZTNFR9 ;Tumor necrosis factor receptor like protein ZTNFR9 ;Tumor necrosis factor receptor superfamily member 10b ;Tumor necrosis factor receptor superfamily, member 10b ;ZTNFR9 |
| Description | TNF receptor superfamily member 10b(TNFRSF10B) Homo sapiens The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009], |
| Cell Pathway/ Category | Cytokine-cytokine receptor interaction,p53,Apoptosis_Inhibition,Apoptosis_Mitochondrial,Apoptosis_Overview,Natural killer cell mediated cytotoxicity, |
| Protein Expression | Cervix,Foreskin fibroblast,Human colon endothel primary cell cultur |
| Subcellular Localization | intracellular,plasma membrane,integral component of plasma membrane,cell surface,integral component of membrane, |
| Protein Function | disease:Defects in TNFRSF10B may be a cause of squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355].,function:Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.,induction:TNFRSF10B is regulated by the tumor suppressor p53.,similarity:Contains 1 death domain.,similarity:Contains 3 TNFR-Cys repeats.,subunit:Homotrimer. Can interact with TRADD and RIP.,tissue specificity:Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLa S3, K562, HL-60, SW480, A549 and G361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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