ITM1361
ITM1361
- Catalog: ITM1361
- Gene/Protein: FADD
- Product Description: Immunotag™ FADD mouse mAb
405.0000
Price in reward points: 405
| Antibody Specification | |
| Datasheet | 
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| Target Protein | FADD |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB |
| Recommended Dilution | wb 1:500 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Recombinant human FADD protein. |
| Specificity | This antibody detects endogenous levels of FADD and does not cross-react with related proteins. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | FADD |
| Accession No. | Q13158 Q61160 |
| Alternate Names | FADD;FADD protein;FADD_HUMAN;Fas (TNFRSF6) associated via death domain;Fas associated via death domain;Fas associating death domain containing protein;Fas associating death domain containing protein;Fas associating protein;Fas associating protein with death domain;Fas associating protein with death domain;Fas TNFRSF6 associated via death domain;FAS-associated death domain protein;FAS-associating death domain-containing protein;FasTNFRSF6 associated via death domain;FasTNFRSF6 associated via death domain; GIG 3;GIG3;Growth inhibiting gene 3 protein;Growth-inhibiting gene 3 protein;H sapiens mRNA for mediator of receptor induced toxicity;H sapiens mRNA for mediator of receptor induced toxicity;Mediator of receptor induced toxicity;Mediator of receptor induced toxicity;MGC8528;MGC8528;MORT 1;MORT1;MORT1;Protein FADD. |
| Description | Fas associated via death domain(FADD) Homo sapiens The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Apoptosis_Inhibition,Apoptosis_Mitochondrial,Apoptosis_Overview,Toll_Like,RIG-I-like receptor,Alzheimer's disease,Pathways in cancer, |
| Protein Expression | Lung,Umbilical vein endothelial cell, |
| Subcellular Localization | cytoplasm,cytosol,plasma membrane,death-inducing signaling complex,CD95 death-inducing signaling complex,neuron projection,cell body,membrane raft,ripoptosome, |
| Protein Function | domain:Contains a death domain involved in the binding of the corresponding domain within Fas receptor.,function:Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis.,PTM:Phosphorylated.,similarity:Contains 1 death domain.,similarity:Contains 1 DED (death effector) domain.,subunit:Interacts with CFLAR, PEA15 and MBD4. When phosphorylated, part of a complex containing HIPK3 and FAS. May interact with MAVS/IPS1. Interacts with MOCV v-CFLAR protein and LRDD.,tissue specificity:Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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