ITM1393
ITM1393
- Catalog: ITM1393
- Gene/Protein: brap
- Product Description: Immunotag™ BRAP mouse mAb
405.0000
Price in reward points: 405
| Antibody Specification | |
| Datasheet | 
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| Target Protein | BRAP |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB |
| Recommended Dilution | wb dilution 1:1000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Purified recombinant human BRAP protein fragments expressed in E.coli. |
| Specificity | This antibody detects endogenous levels of BRAP and does not cross-react with related proteins. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | brap |
| Accession No. | Q7Z569 Q99MP8 |
| Alternate Names | 3010002G07Rik;BRAP2;BRCA1 associated protein;EC 6.3.2.;Galectin 2 binding protein;IMP; Impedes mitogenic signal propagation;Renal carcinoma antigen NY REN 63; RING finger protein 52;RNF52;zgc:92894. |
| Description | BRCA1 associated protein(BRAP) Homo sapiens The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. [provided by RefSeq, Jul 2008], |
| Protein Expression | Brain,Fibroblast,Renal cell carcinoma,T-cell,Testicle, |
| Subcellular Localization | ubiquitin ligase complex,cytoplasm,cytosol,nuclear membrane, |
| Protein Function | function:Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 1 UBP-type zinc finger.,subunit:Interacts with the nuclear localization signal of BRCA1 and with the N-terminal of KSR1. The C-terminal portion of BCRA1 interacts with DDB1.,tissue specificity:Expressed in breast epithelial cell lines., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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