ITM1394
ITM1394
- Catalog: ITM1394
- Gene/Protein: hr23b
- Product Description: Immunotag™ hHR23b mouse mAb
405.0000
Price in reward points: 405
| Antibody Specification | |
| Datasheet | 
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| Target Protein | hHR23b |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ICC,IHC |
| Recommended Dilution | wb dilution 1:1000 icc dilution 1:100 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat,Monkey,Hamster |
| Host Species | Mouse |
| Immunogen | Purified recombinant human hHR23b protein fragments expressed in E.coli. |
| Specificity | This antibody detects endogenous levels of hHR23b and does not cross-react with related proteins. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | hr23b |
| Accession No. | P54727 P54728 |
| Alternate Names | hHR 23b;hHR23B;HR 23B;HR23B;mHR 23B;mHR23B;P58;RAD 23B;RAD23 (S. cerevisiae) homolog B; RAD23 homolog B (S. cerevisiae);RAD23 homolog B;RAD23 yeast homolog of B;RAD23B; RD23B_HUMAN;UV excision repair protein RAD23 homolog B;XP C repair complementing complex 58 kDa;XP C repair complementing complex 58 kDa protein;XP C repair complementing protein;XP-C repair-complementing complex 58 kDa protein;XPC repair complementing complex 58 kDa;XPC repair complementing complex 58 kDa protein;XPC repair complementing protein. |
| Description | RAD23 homolog B, nucleotide excision repair protein(RAD23B) Homo sapiens The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2011], |
| Cell Pathway/ Category | Nucleotide excision repair, |
| Protein Expression | Epithelium,Testis,Thymus,Uterus, |
| Subcellular Localization | proteasome complex,nucleus,nucleoplasm,cytoplasm,XPC complex, |
| Protein Function | domain:The ubiquitin-like domain mediates interaction with MJD.,function:Plays a central role both in proteosomal degradation of misfolded proteins and DNA repair. Central component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulun that are retrotranslocated in the cytosol. Involved in DNA excision repair by stabilizing XPC protein. May play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes.,similarity:Belongs to the RAD23 family.,similarity:Contains 1 STI1 domain.,similarity:Contains 1 ubiquitin-like domain.,similarity:Contains 2 UBA domains.,subunit:Component of a complex required to couple retrotranslocation, ubiquitination and deglycosylation composed of NGLY1, SAKS1, AMFR, VCP and RAD23B (By similarity). Interacts with the 26S proteasome. Interacts directly with NGLY1. Heterodimer of a 125 kDa subunit (p125) and of a 58 kDa subunit (p58). Interacts with MJD and XPC., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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