ITM1403
ITM1403
- Catalog: ITM1403
- Gene/Protein: mapk8
- Product Description: Immunotag™ JNK1 mouse mAb
405.0000
Price in reward points: 405
| Antibody Specification | |
| Datasheet | 
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| Target Protein | JNK1 |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IF |
| Recommended Dilution | wb dilution 1:1000 icc dilution 1:100 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Mouse |
| Immunogen | Purified recombinant human JNK1 protein fragments expressed in E.coli. |
| Specificity | This antibody detects endogenous levels of JNK1 and does not cross-react with related proteins. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | mapk8 |
| Accession No. | P45983 Q91Y86 |
| Alternate Names | AI849689 ;c Jun N terminal kinase 1 ;C-JUN kinase 1 ;c-Jun N-terminal kinase 1 ;EC 2.7.11.24 ;JAK 1A ;JAK1A ;JNK 1 ;JNK 46 ;JNK ;JNK-46 ;JNK1A2 ;JNK21B1/2 ;MAP kinase 8 ;MAPK 8 ;MAPK8 ;Mitogen activated protein kinase 8 ;Mitogen-activated protein kinase 8 ;MK08_HUMAN ;p54 gamma ;PRKM 8 ;PRKM8 ;Protein kinase JNK1 ;Protein kinase, mitogen-activated, 8 ;SAPK 1 ;SAPK gamma ;SAPK1 ;Stress activated protein kinase JNK1 ;Stress-activated protein kinase 1 ;Stress-activated protein kinase JNK1 ;Tyrosine protein kinase JAK1 . |
| Description | mitogen-activated protein kinase 8(MAPK8) Homo sapiens The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spl |
| Cell Pathway/ Category | MAPK_ERK_Growth,MAPK_G_Protein,ErbB_HER,WNT,WNT-T CELLFocal adhesion,Toll_Like,NOD-like receptor,RIG-I-like receptor,Fc epsilon RI,Neurotrophin,Insulin_Receptor,GnRH,Progesterone-mediated oocyte maturation,Adipocytokine,Type II diabetes mellitus,Epithelial cell signaling in Helicobacter pylori infection,Pathways in cancer,Colorectal cancer,Pancreatic cancer, |
| Protein Expression | Brain,Epithelium,Fetal brain,Lung,Pooled,Testis, |
| Subcellular Localization | intracellular,nucleus,nucleoplasm,mitochondrion,cytosol, |
| Protein Function | catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.,enzyme regulation:Activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. Inhibited by dual specificity phosphatases, such as DUSP1.,function:JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.,function:Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells (By similarity). Phosphorylates heat shock factor protein 4 (HSF4).,online information:C-Jun N-terminal kinases entry,PTM:Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway. Interacts with TP53 and WWOX. Interacts with JAMP. Forms a complex with MAPK8IP1 and RGNEF (By similarity). Interacts with NFATC4., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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