ITM1417
ITM1417
- Catalog: ITM1417
- Gene/Protein: xrcc1
- Product Description: Immunotag™ XRCC1 mouse mAb
405.0000
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Antibody Specification | |
Datasheet | |
Target Protein | XRCC1 |
Clonality | Monoclonal |
Storage/Stability | -20°C/1 year |
Application | WB |
Recommended Dilution | wb dilution 1:1000 |
Concentration | 1 mg/ml |
Reactive Species | Human |
Host Species | Mouse |
Immunogen | Purified recombinant human XRCC1 protein fragments expressed in E.coli. |
Specificity | This antibody detects endogenous levels of XRCC1 and does not cross-react with related proteins. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | xrcc1 |
Accession No. | P18887 Q60596 |
Alternate Names | DNA repair protein XRCC1;RCC;X ray repair complementing defective repair in chinese hamster;X ray repair complementing defective repair in chinese hamster cells 1;X ray Repair Complementing Defective Repair in Chinese Hamster Cells;X ray repair cross complementing protein 1;X ray repair, complementing defective, repair in Chinese hamster;X-ray repair cross-complementing protein 1;XRCC 1;Xrcc1;XRCC1_HUMAN. |
Description | X-ray repair cross complementing 1(XRCC1) Homo sapiens The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008], |
Cell Pathway/ Category | Base excision repair, |
Protein Expression | Brain,Epithelium,Placenta, |
Subcellular Localization | nucleus,nucleoplasm, |
Protein Function | function:Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.,polymorphism:Carriers of the polymorphic Gln-399 allele may be at greater risk for tobacco- and age-related DNA damage.,PTM:Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF.,PTM:Sumoylated.,similarity:Contains 2 BRCT domains.,subcellular location:Accumulates at sites of DNA damage.,subunit:Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |