ITM1420
ITM1420
- Catalog: ITM1420
- Gene/Protein: gadd45a
- Product Description: Immunotag™ GADD45α mouse mAb
405.0000
Price in reward points: 405
| Antibody Specification | |
| Datasheet | 
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| Target Protein | GADD45α |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB |
| Recommended Dilution | wb dilution 1:1000 |
| Concentration | 1 mg/ml |
| Reactive Species | Transfected |
| Host Species | Mouse |
| Immunogen | Purified recombinant human GADD45 α protein expressed in E.coli |
| Specificity | Transfected Only. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | gadd45a |
| Accession No. | P24522 P48316 |
| Alternate Names | DDIT 1; DDIT-1; DDIT1; DNA damage inducible transcript 1; DNA damage-inducible transcript 1 protein; GA45A_HUMAN; GADD45; GADD45A; Growth arrest and DNA damage inducible 45 alpha; Growth arrest and DNA damage inducible alpha; Growth arrest and DNA damage-inducible protein GADD45 alpha. |
| Description | growth arrest and DNA damage inducible alpha(GADD45A) Homo sapiens This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010], |
| Cell Pathway/ Category | MAPK_ERK_Growth,MAPK_G_Protein,Cell_Cycle_G1S,Cell_Cycle_G2M_DNA,p53, |
| Protein Expression | Bronchial epithelial cells treated with 20 uM arsenic for 4 |
| Subcellular Localization | nucleus,nucleoplasm,cytoplasm, |
| Protein Function | disease:Induction of GADD45 in ataxia telangiectasia cells is abnormal.,function:Binds to proliferating cell nuclear antigen. Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase.,induction:By UV radiation, X-rays, growth arrest and alkylating agents. The induction is mediate by some kinase(s) other than PKC.,similarity:Belongs to the GADD45 family.,subunit:Interacts with GADD45GIP1., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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