ITM1422
ITM1422
- Catalog: ITM1422
- Gene/Protein: ftl
- Product Description: Immunotag™ Ferritin Light Chain mouse mAb
405.0000
Price in reward points: 405
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Ferritin (LC) |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | ELISA |
| Recommended Dilution | ELISA 1:10000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Purified recombinant full length of human ferritin light chain protein expressed in E.coli. |
| Specificity | This antibody detects recombinant ferritin proteins. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | ftl |
| Accession No. | P02792 |
| Alternate Names | Ferritin L chain ; Ferritin L subunit ; Ferritin light chain ; Ferritin light polypeptide ; Ferritin light polypeptide like 3 ; FRIL ; FRIL_HUMAN ; FTL ; L apoferritin ; LFTD ; MGC71996 ; NBIA 3 ; NBIA3. |
| Description | ferritin light chain(FTL) Homo sapiens This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008], |
| Protein Expression | Brain,Colon endothelium,Kidney,Liver,Placenta,Skin,Testis,Urinary bladder, |
| Subcellular Localization | cell,cytoplasm,cytosol,intracellular ferritin complex,membrane,autolysosome,extracellular exosome, |
| Protein Function | disease:Defects in FTL are the cause of hereditary hyperferritinemia-cataract syndrome (HHCS) [MIM:600886]. It is an autosomal dominant disease characterized by early-onset bilateral cataract. Affected patients have elevated level of circulating ferritin. HHCS is caused by mutations in the iron responsive element (IRE) of the FTL gene.,disease:Defects in FTL are the cause of neuroferritinopathy [MIM:606159]; also known as adult-onset basal ganglia disease. It is a movement disorder with heterogeneous presentations starting in the fourth to sixth decade. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels.,function:Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis.,function:Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney.,online information:Ferritin entry,similarity:Belongs to the ferritin family.,similarity:Contains 1 ferritin-like diiron domain.,subunit:Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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