ITM1445
ITM1445
- Catalog: ITM1445
- Gene/Protein: rbbp5
- Product Description: Immunotag™ RBBP5 mouse mAb
405.0000
Price in reward points: 405
| Antibody Specification | |
| Datasheet | 
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| Target Protein | RBBP5 |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IF |
| Recommended Dilution | wb dilution 1:1000 icc dilution 1:100 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Mouse |
| Immunogen | Purified recombinant human RBBP5 protein fragments expressed in E.coli. |
| Specificity | This antibody detects endogenous levels of RBBP5 and does not cross-react with related proteins. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | rbbp5 |
| Accession No. | Q15291 Q8BX09 |
| Alternate Names | RBBP 5; RBBP-5; RBBP5; RBBP5_HUMAN; RBQ 3; RBQ3; Retinoblastoma binding protein 5; Retinoblastoma binding protein RBQ3; Retinoblastoma binding protein5; Retinoblastoma-binding protein 5; Retinoblastoma-binding protein RBQ-3; SWD1; SWD1, Set1c WD40 repeat protein, homolog. |
| Description | RB binding protein 5, histone lysine methyltransferase complex subunit(RBBP5) Homo sapiens This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2010], |
| Protein Expression | Brain,Epithelium,Lung carcinoma,Tes |
| Subcellular Localization | nucleus,nucleoplasm,nucleolus,histone methyltransferase complex,MLL3/4 complex,Set1C/COMPASS complex,MLL1 complex, |
| Protein Function | function:Binds preferentially to underphosphorylated retinoblastoma protein.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 6 WD repeats.,subunit:Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2/ASH2L and CXXC1/CFP1. Component of MLL-containing complexes (named MLL, ASCOM, MLL2/MLL3 or MLL3/MLL4 complex): at least composed ASH2L, RBBP5, DPY30, WDR5, one or several histone methyltransferases (MLL, MLL2, MLL3 and/or MLL4), and the facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP and C16orf53/PA1.,tissue specificity:Ubiquitously expressed., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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