ITM1455
ITM1455
- Catalog: ITM1455
- Gene/Protein: eif4ebp3
- Product Description: Immunotag™ EIF4EBP3 mouse mAb
405.0000
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Antibody Specification | |
Datasheet | |
Target Protein | EIF4EBP3 |
Clonality | Monoclonal |
Storage/Stability | -20°C/1 year |
Application | WB |
Recommended Dilution | wb dilution 1:1000 |
Concentration | 1 mg/ml |
Reactive Species | Transfected |
Host Species | Mouse |
Immunogen | Recombinant protein of human EIF4EBP3. |
Specificity | Transfected Only. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | eif4ebp3 |
Accession No. | O60516 Q80VV3 |
Alternate Names | 4E BP3; 4E-BP3; 4EBP3; eIF4E binding protein 3; Eukaryotic initiation factor 4E binding protein 3; Eukaryotic translation initiation factor 4E binding protein 3; OTTHUMP00000159879. |
Description | eukaryotic translation initiation factor 4E binding protein 3(EIF4EBP3) Homo sapiens This gene encodes a member of the EIF4EBP family, which consists of proteins that bind to eukaryotic translation initiation factor 4E and regulate its assembly into EIF4F, the multi-subunit translation initiation factor that recognizes the mRNA cap structure. Read-through transcription from the neighboring upstream gene (MASK or ANKHD1) generates a transcript (MASK-BP3) that encodes a protein comprised of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments. [provided by RefSeq, Oct 2010], |
Protein Expression | Brain,Embryo,Lung,Lymph,Mammary gland,Skin, |
Subcellular Localization | cytoplasm,membrane,eukaryotic translation initiation factor 4F complex, |
Protein Function | function:May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases.,function:Regulates eIF4E activity by preventing its assembly into the eIF4F complex.,PTM:Phosphorylated.,similarity:Belongs to the eIF4E-binding protein family.,similarity:Belongs to the mask family.,similarity:Contains 1 KH domain.,similarity:Contains 25 ANK repeats.,subunit:EIF4EBP3 interacts with EIF4E.,subunit:Interacts with PTPN11. Isoform 2 interacts with VPR.,tissue specificity:Expression is highest in skeletal muscle, heart, kidney, and pancreas, whereas there is very little expression in brain and thymus.,tissue specificity:Ubiquitous with high expression in cervix, spleen and brain. Expressed in hematopoietic cells with increased expression in leukemia cells. Isoform 2 is highly expressed in spleen with almost no expression in muscle and brain., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |