ITM1500
ITM1500
- Catalog: ITM1500
- Gene/Protein: wnt3
- Product Description: Immunotag™ Wnt3 mouse mAb
405.0000
Price in reward points: 405
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Wnt-3a |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB |
| Recommended Dilution | wb dilution 1:1000 |
| Concentration | 1 mg/ml |
| Reactive Species | Transfected |
| Host Species | Mouse |
| Immunogen | Purified recombinant human Wnt3 protein fragments expressed in E.coli. |
| Specificity | Transfected Only. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | wnt3 |
| Accession No. | P56703 P17553 |
| Alternate Names | Int 4;INT4;MGC131950;MGC138321;MGC138323;Proto-oncogene Int-4 homolog;Proto-oncogene Wnt-3;wingless type MMTV integration site family member 3;Wnt 3 proto oncogene protein;WNT 3 proto oncogene protein precursor;wnt3;WNT3_HUMAN. |
| Description | Wnt family member 3(WNT3) Homo sapiens The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | WNT,WNT-T CELLHedgehog,Melanogenesis,Pathways in cancer,Basal cell carcinoma, |
| Subcellular Localization | extracellular region,proteinaceous extracellular matrix,extracellular space,endoplasmic reticulum lumen,Golgi lumen,plasma membrane,endocytic vesicle membrane,extracellular exosome,Wnt signalosome, |
| Protein Function | disease:Defects in WNT3 are the cause of autosomal recessive tetra-amelia [MIM:273395]. Tetra-amelia is a rare human genetic disorder characterized by complete absence of all four limbs and other anomalies such as craniofacial, nervous system, pulmonary, skeletal and urogenital defects.,function:Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube.,similarity:Belongs to the Wnt family.,subunit:Interacts with PORCN., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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