ITM3074
ITM3074
- Catalog: ITM3074
- Gene/Protein: ABCB5
- Product Description: Immunotag™ ABCB5 Monoclonal Antibody(11A2)
405.0000
Price in reward points: 405
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | ABCB5 (11A2) |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,IF, |
| Recommended Dilution | WB: 1:2000 IF 1:200 IHC 1:50-300 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Synthetic Peptide of ABCB5 |
| Specificity | The antibody detects endogenous ABCB5 proteins. |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen |
| Form | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. |
| Gene Name | ABCB5 |
| Accession No. | Q2M3G0 |
| Alternate Names | ABCB5; ATP-binding cassette sub-family B member 5; ABCB5 P-gp; P-glycoprotein ABCB5 |
| Description | ATP binding cassette subfamily B member 5(ABCB5) Homo sapiens ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules (Chen et al., 2005 [PubMed 15760339]).[supplied by OMIM, Mar 2008], |
| Cell Pathway/ Category | ABC transporters, |
| Protein Expression | Brain,Lung,Melanocyte,Melanoma,Pancreas,Testis, |
| Subcellular Localization | plasma membrane,integral component of plasma membrane,integral component of membrane, |
| Protein Function | caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,caution:Was named ABCB1 by some authors.,function:Plasma membrane transporter able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Responsible for the resistance to doxorubicin of a subset of malignant melanomas.,miscellaneous:Depletion of ABCB5 by RNAi increases the sensitivity to several drugs of a subset of melanoma cells.,similarity:Belongs to the ABC transporter family.,similarity:Belongs to the ABC transporter family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.,similarity:Contains 1 ABC transmembrane type-1 domain.,similarity:Contains 1 RRM (RNA recognition motif) domain.,similarity:Contains 2 ABC transporter domains.,subunit:Component of the U11/U12 snRNPs that are part of the U12-type spliceosome.,tissue specificity:Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Also expressed in several malignant tissues.,tissue specificity:Expressed in heart, liver, skeletal muscle and pancreas., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
| English_US |
|
| Danish |
|
| Dutch |
|
| English_UK |
|
| French |
|
| German |
|
| Spanish |
|
| Norwegian |
|
| Portuguese |
|
| Finnish |
|
| Swedish |
|
| Polish |
|