ITM3227
ITM3227
- Catalog: ITM3227
- Gene/Protein: GAPDH
- Product Description: Immunotag™ GAPDH Polyclonal Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | GAPDH |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB |
Recommended Dilution | WB: 1:2000-5000 |
Concentration | 1 mg/ml |
Reactive Species | Zebrafisheep |
Host Species | Rabbit |
Immunogen | Recombinant Protein of Glyceraldehyde-3-phosphate dehydrogenase |
Specificity | The antibody detects Zebrafish endogenous GAPDH protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen |
Form | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. |
Gene Name | GAPDH |
Accession No. | P04406 P16858 P04797 |
Alternate Names | GAPDH; GAPD; CDABP0047; OK/SW-cl.12; Glyceraldehyde-3-phosphate dehydrogenase; GAPDH; Peptidyl-cysteine S-nitrosylase GAPDH |
Description | glyceraldehyde-3-phosphate dehydrogenase(GAPDH) Homo sapiens This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferri |
Cell Pathway/ Category | Glycolysis / Gluconeogenesis,Alzheimer's disease, |
Protein Expression | Astrocytoma,Brain,Cajal-Retzius cell,Colon adenocarcinoma,Epitheliu |
Subcellular Localization | nucleus,cytoplasm,lipid particle,cytosol,plasma membrane,microtubule cytoskeleton,membrane,intracellular ribonucleoprotein complex,extracellular matrix,nuclear membrane,vesicle,intracellular membrane-bounded orga |
Protein Function | catalytic activity:D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH.,function:Independent of its glycolytic activity it is also involved in membrane trafficking in the early secretory pathway.,online information:Glyceraldehyde 3-phosphate dehydrogenase entry,pathway:Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1.,pathway:Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.,PTM:Reversible S-nitrosylation of Cys-152 inhibits enzymatic activity and increases endogenous ADP-ribosylation, which inhibits the enzyme in a non-reversible manner. The latter modification is more likely to be a pathophysiological event associated with inhibition of gluconeogenesis.,sequence caution:Differs quite extensively.,similarity:Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.,subcellular location:Postnuclear and Perinuclear regions.,subunit:Homotetramer.,subunit:Homotetramer. Binds PRKCI., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |