ITM3371
ITM3371
- Catalog: ITM3371
- Gene/Protein: SNAI2
- Product Description: Immunotag™ SLUG Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | SLUG |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p |
| Recommended Dilution | WB: 1:500-1000 IHC: 1:200-500 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Recombinant Protein of SLUG |
| Specificity | The antibody detects endogenous SLUG protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. |
| Gene Name | SNAI2 |
| Accession No. | O43623 P97469 O08954 |
| Alternate Names | SNAI2; SLUG; SLUGH; Zinc finger protein SNAI2; Neural crest transcription factor Slug; Protein snail homolog 2 |
| Description | snail family transcriptional repressor 2(SNAI2) Homo sapiens This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Adherens_Junction, |
| Protein Expression | Dermoid cancer,Uterus, |
| Subcellular Localization | nuclear chromatin,nucleus,cytoplasm, |
| Protein Function | disease:Defects in SNAI2 are a cause of neural tube defects (NTD).,disease:Defects in SNAI2 are the cause of Waardenburg syndrome type 2D (WS2D) [MIM:608890]. WS2 is a genetically heterogeneous, autosomal dominant disorder characterized by sensorineural deafness, pigmentary disturbances, and absence of dystopia canthorum. The frequency of deafness is higher in WS2 than in WS1.,function:Transcriptional repressor. Involved in the generation and migration of neural crest cells.,similarity:Belongs to the snail C2H2-type zinc-finger protein family.,similarity:Contains 5 C2H2-type zinc fingers.,tissue specificity:Expressed in placenta and adult heart, pancreas, liver, kidney and skeletal muscle., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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