ITM3402
ITM3402
- Catalog: ITM3402
- Gene/Protein: CYCS
- Product Description: Immunotag™ CYCS Monoclonal Antibody(4B10)
405.0000
Price in reward points: 405
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | CYCS (4B10) |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IF,IHC-p |
| Recommended Dilution | WB: 1:1000-5000 IHC: 1:500-1000 IF 1:200 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat,Chicken |
| Host Species | Mouse |
| Immunogen | Recombinant Protein of CYCS |
| Specificity | The antibody detects endogenous CYCS protein. |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen |
| Form | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. |
| Gene Name | CYCS |
| Accession No. | P99999 P62897 P62898 |
| Alternate Names | CYCS; CYC; Cytochrome c |
| Description | cytochrome c, somatic(CYCS) Homo sapiens This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. This protein is also involved in initiation of apoptosis. Mutations in this gene are associated with autosomal dominant nonsyndromic thrombocytopenia. Numerous processed pseudogenes of this gene are found throughout the human genome.[provided by RefSeq, Jul 2010], |
| Cell Pathway/ Category | p53,Apoptosis_Inhibition,Apoptosis_Mitochondrial,Apoptosis_Overview,Alzheimer's disease,Parkinson's disease,Amyotrophic lateral sclerosis (ALS),Huntington's disease,Pathways in cancer,Colorectal cancer,Small cell lung cancer,Viral myocarditis, |
| Protein Expression | Amygdala,Bone marrow,Brain,Embryo,Heart,Kidney,Lung,Skeletal muscle,Skin,Testis,Uri |
| Subcellular Localization | protein phosphatase type 2A complex,nucleus,mitochondrion,mitochondrial inner membrane,mitochondrial intermembrane space,cytosol,respiratory chain, |
| Protein Function | disease:Defects in CYCS are the cause of thrombocytopenia type 4 (THC4) [MIM:612004]; also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation.,function:Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.,function:Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.,online information:Life shuttle - Issue 76 of November 2006,PTM:Binds 1 heme group per subunit.,similarity:Belongs to the cytochrome c family., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
| English_US |
|
| Danish |
|
| Dutch |
|
| English_UK |
|
| French |
|
| German |
|
| Spanish |
|
| Norwegian |
|
| Portuguese |
|
| Finnish |
|
| Swedish |
|
| Polish |
|