ITM3430
ITM3430
- Catalog: ITM3430
- Gene/Protein: MICU1
- Product Description: Immunotag™ MICU1 Monoclonal Antibody(Mix)
405.0000
Price in reward points: 405
| Antibody Specification | |
| Datasheet | 
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| Target Protein | MICU1 (Mix) |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IF,IHC-p |
| Recommended Dilution | WB: 1:1000-2000 IHC: 1:100-200 IF 1:200 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Mouse |
| Immunogen | Recombinant Protein of MICU1 |
| Specificity | The antibody detects endogenous MICU1 protein. |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen |
| Form | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. |
| Gene Name | MICU1 |
| Accession No. | Q9BPX6 Q8VCX5 Q6P6Q9 |
| Alternate Names | Calcium uptake protein 1, mitochondrial; Atopy-related autoantigen CALC; ara CALC; Calcium-binding atopy-related autoantigen 1; allergen Hom s 4 |
| Description | mitochondrial calcium uptake 1(MICU1) Homo sapiens This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2013], |
| Protein Expression | Brain,Muscle,Skin, |
| Subcellular Localization | intracellular,mitochondrion,mitochondrial inner membrane,mitochondrial intermembrane space,integral component of mitochondrial membrane,calcium channel complex,uniplex complex, |
| Protein Function | allergen:Causes an allergic reaction in human. Binds to IgE from atopic dermatitis (AD) patients. Identified as an IgE autoantigen in atopic dermatitis (AD) patients with severe skin manifestations.,function:Induces T helper 1-mediated autoreactivity, which is accompanied by the release of IFNG.,sequence caution:Contaminating sequence. Sequence of unknown origin in the N-terminal part.,similarity:Contains 2 EF-hand domains.,tissue specificity:Expressed in epithelial cell line. Strongly expressed in epidermal keratinocytes and dermal endothelial cells., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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