ITM3449
ITM3449
- Catalog: ITM3449
- Gene/Protein: Lysine
- Product Description: Immunotag™ Acetyl Lysine Monoclonal Antibody(10B10)
460.0000
Price in reward points: 460
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Lysine (10B10) |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p |
| Recommended Dilution | WB: 1:500-1:2000, EIA: 1:10000 |
| Concentration | 1 mg/ml |
| Reactive Species | All |
| Host Species | Mouse |
| Immunogen | Purified Protein |
| Specificity | The antibody detects endogenous Acetyl Lysine protein. |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
| Gene Name | Lysine |
| Description | Acetylation of lysine, like phosphorylation of serine, threonine or tyrosine, is an important reversible modification controlling protein activity. The conserved amino-terminal domains of the four core histones (H2A, H2B, H3, and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs). Signaling resulting in acetylation/deacetylation of histones, transcription factors, and other proteins affects a diverse array of cellular processes including chromatin structure and gene activity, cell growth, differentiation, and apoptosis. Recent proteomic surveys suggest that acetylation of lysine residues may be a widespread and important form of posttranslational protein modification that affects thousands of proteins involved in control of cell cycle and metabolism, longevity, actin polymerization, and nuclear transport. The regulation of protein acetylation status is impaired in cancer and polyglutamine diseases , and HDACs have become promising targets for anti-cancer drugs currently in development. |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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