ITM3491
ITM3491
- Catalog: ITM3491
- Gene/Protein: CABP1
- Product Description: Immunotag™ CABP Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | CABP |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Rat,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthetic Peptide of CABP |
| Specificity | The antibody detects endogenous CABP protein |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | CABP1 |
| Accession No. | Q9NZU7 Q9JLK7 O88751 |
| Alternate Names | Calcium-binding protein 1 (CaBP1) (Calbrain) (Caldendrin) |
| Description | calcium binding protein 1(CABP1) Homo sapiens Calcium binding proteins are an important component of calcium mediated cellular signal transduction. This gene encodes a protein that belongs to a subfamily of calcium binding proteins which share similarity to calmodulin. The protein encoded by this gene regulates the gating of voltage-gated calcium ion channels. This protein inhibits calcium-dependent inactivation and supports calcium-dependent facilitation of ion channels containing voltage-dependent L-type calcium channel subunit alpha-1C. This protein also regulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors, P/Q-type voltage-gated calcium channels, and transient receptor potential channel TRPC5. This gene is predominantly expressed in retina and brain. Alternative splicing results in multiple transcript variants encoding disinct isoforms. [provided by RefSeq, Jul 2012], |
| Protein Expression | Cerebellum,Retina, |
| Subcellular Localization | Golgi membrane,extracellular space,cytoskeleton,plasma membrane,cell cortex,postsynaptic density,cell junction,postsynaptic membrane,perinuclear region of cytoplasm, |
| Protein Function | Experimental confirmation may be lacking for some isoforms,similarity:Contains 4 EF-hand domains.,subcellular location:L-CaBP1 is associated most likely with the cytoskeletal structures, whereas S-CaBP1 is localized at or near the plasma membrane.,subunit:Interacts with MYO1C.,tissue specificity:Retina and brain. Calbrain was found exclusively in brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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