ITM3543
ITM3543
- Catalog: ITM3543
- Gene/Protein: CLIC4
- Product Description: Immunotag™ CLIC4 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | CLIC4 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p |
| Recommended Dilution | WB 1:1000-2000, IHC 1:100-200 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthetic Peptide of CLIC4 |
| Specificity | CLIC4 protein(A217) detects endogenous levels of CLIC4 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | CLIC4 |
| Accession No. | Q9Y696 Q9QYB1 Q9Z0W7 |
| Alternate Names | CLIC4; Chloride intracellular channel protein 4; Intracellular chloride ion channel protein p64H1 |
| Description | chloride intracellular channel 4(CLIC4) Homo sapiens Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). [provided by RefSeq, Jul 2008], |
| Protein Expression | Kidney,Ovary,Placenta,Platelet, |
| Subcellular Localization | intracellular,cytoplasm,mitochondrion,centrosome,cytosol,plasma membrane,microvillus,cell-cell junction,cell surface,actin cytoskeleton,microtubule cytoskeleton,nuclear matrix,midbody,cytoplasmic ve |
| Protein Function | domain:Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.,function:Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. May play a role in angiogenesis.,induction:Up-regulated by calcium ions in differentiating keratinocytes.,similarity:Belongs to the chloride channel CLIC family.,similarity:Contains 1 GST C-terminal domain.,subcellular location:Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles.,subunit:Monomer. Interacts with HRH3.,tissue specificity:Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, placenta and skeletal muscle., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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