ITM3568
ITM3568
- Catalog: ITM3568
- Gene/Protein: SLC12A4
- Product Description: Immunotag™ SLC12A4 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | SLC12A4 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p |
| Recommended Dilution | WB 1:1000-2000, IHC 1:100-200 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthetic Peptide of SLC12A4 |
| Specificity | SLC12A4 protein(A248) detects endogenous levels of SLC12A4 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | SLC12A4 |
| Accession No. | Q9UP95 Q9JIS8 Q63632 |
| Alternate Names | Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (hKCC1) |
| Description | solute carrier family 12 member 4(SLC12A4) Homo sapiens This gene encodes a member of the SLC12A transporter family. The encoded protein mediates the coupled movement of potassium and chloride ions across the plasma membrane. This gene is expressed ubiquitously. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2013], |
| Protein Expression | Cerebellum,Embryonic kidney,Erythroleukemia,Eye,Testis, |
| Subcellular Localization | lysosomal membrane,plasma membrane,integral component of plasma membrane,membrane,integral component of membrane, |
| Protein Function | Experimental confirmation may be lacking for some isoforms,function:Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity.,PTM:N-glycosylated.,similarity:Belongs to the SLC12A transporter family.,subunit:Homomultimer and heteromultimer with other K-Cl cotransporters.,tissue specificity:Ubiquitous. Levels are much higher in erythrocytes from patients with Hb SC and Hb SS compared to normal AA erythrocytes. This may contribute to red blood cell dehydration and to the manifestation of sickle cell disease by increasing the intracellular concentration of HbS. Isoform 1 was not detected in circulating reticulocytes., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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