ITM3572
ITM3572
- Catalog: ITM3572
- Gene/Protein: KCNAB1
- Product Description: Immunotag™ KVβ1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | KVβ1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p |
| Recommended Dilution | IHC 1:100-200 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthetic Peptide of KVβ1 |
| Specificity | KVβ1 protein(A255) detects endogenous levels of KVβ1 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | KCNAB1 |
| Accession No. | Q14722 P63143 P63144 |
| Alternate Names | Voltage-gated potassium channel subunit beta-1 (K(+) channel subunit beta-1) (Kv-beta-1) |
| Description | potassium voltage-gated channel subfamily A member regulatory beta subunit 1(KCNAB1) Homo sapiens Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes distinct isoforms which are encoded by alternatively spliced transcript variants of this gene. Some of these isoforms are beta subunits, which form heteromultimeric complexes with alpha subunits and modulate the activity of the pore-forming alp |
| Protein Expression | Brain,Brain cortex,Heart,He |
| Subcellular Localization | cytoplasm,cytosol,plasma membrane,voltage-gated potassium channel complex,integral component of membrane,extrinsic component of cytoplasmic side of plasma membrane,dendrite cytoplasm,potassium channel complex, |
| Protein Function | domain:Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit.,function:Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. All three isoforms alter the functional properties of Kv1.4 and Kv1.5. Isoform KvB1.2 has no effect on Kv1.1, Kv1.2 or Kv2.1.,similarity:Belongs to the shaker potassium channel beta subunit family.,subunit:Forms heteromultimeric complex with alpha subunits. Interacts with SQSTM1.,tissue specificity:In brain, expression is most prominent in caudate nucleus, hippocampus and thalamus. Significant expression also detected in amygdala and subthalamic nucleus. Also expressed in both healthy and cardiomyopathic heart. Up to four times more abundant in left ventricle than left atrium., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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