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ITM3577

ITM3577-2
ITM3577-3
ITM3577
ITM3577-2
ITM3577-3
ITM3577
ITM3577
  • Gene/Protein: KCNH5
  • Product Description: Immunotag™ Kv10.2 Polyclonal Antibody
280.0000
Price in reward points: 294

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Immunotag™ Kv10.2 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein KV10.2
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,IHC-p
Recommended Dilution WB 1:1000-2000, IHC 1:100-200
Concentration 1 mg/ml
Reactive Species Human,Rat,Mouse
Host Species Rabbit
Immunogen Synthetic Peptide of Kv10.2
Specificity Kv10.2 protein(A260) detects endogenous levels of Kv10.2
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name KCNH5
Accession No. Q8NCM2 Q920E3 Q9EPI9
Alternate Names Potassium voltage-gated channel subfamily H member 5 (Ether-a-go-go potassium channel 2) (hEAG2) (Voltage-gated potassium channel subunit Kv10.2)
Description potassium voltage-gated channel subfamily H member 5(KCNH5) Homo sapiens This gene encodes a member of voltage-gated potassium channels. Members of this family have diverse functions, including regulating neurotransmitter and hormone release, cardiac function, and cell volume. This protein is an outward-rectifying, noninactivating channel. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],
Protein Expression Brain,Fetal brain,PNS,Skin,
Subcellular Localization intracellular,plasma membrane,integral component of plasma membrane,cell surface,integral component of membrane,
Protein Function Experimental confirmation may be lacking for some isoforms,domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,function:Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly.,sequence caution:Translated as Gly.,similarity:Belongs to the potassium channel family. H (Eag) subfamily.,similarity:Contains 1 cyclic nucleotide-binding domain.,similarity:Contains 1 PAC (PAS-associated C-terminal) domain.,similarity:Contains 1 PAS (PER-ARNT-SIM) domain.,subunit:The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH1/EAG.,tissue specificity:Detected in brain, skeletal muscle, heart, placenta, lung and liver, and at low levels in kidney.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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