ITM3602
ITM3602
- Catalog: ITM3602
- Gene/Protein: RPS6KB1
- Product Description: Immunotag™ P70 S6 Kinase mouse Monoclonal Antibody(1C7)
405.0000
Price in reward points: 405
| Antibody Specification | |
| Datasheet | 
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| Target Protein | P8000 S6 Kinase (1C7) |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p |
| Recommended Dilution | IHC 1:100-200 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat,Mouse |
| Host Species | Mouse |
| Immunogen | Recombinant Protein of P70 S6 Kinase of RPS6KB1 |
| Specificity | P70 S6 Kinase protein detects endogenous levels of RPS6KB1 |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | RPS6KB1 |
| Accession No. | P23443 Q8BSK8 P67999 |
| Alternate Names | RPS6KB1 |
| Description | ribosomal protein S6 kinase B1(RPS6KB1) Homo sapiens This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013], |
| Cell Pathway/ Category | ErbB_HER,mTOR,TGF-beta,Fc gamma R-mediated phagocytosis,Insulin_Receptor,Acute myeloid leukemia, |
| Protein Expression | Epithelium,Eye,Testis, |
| Subcellular Localization | nucleus,nucleoplasm,cytoplasm,mitochondrion,mitochondrial outer membrane,cytosol,cell surface,cell junction,neuron projection,synapse,perinuclear region of cytoplasm, |
| Protein Function | catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Activation by serine/threonine phosphorylation and protein kinase C, inactivated by type 2A phosphatase.,function:Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with PPP1R9A/neurabin-1.,tissue specificity:Widely expressed., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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