ITM3686
ITM3686
- Catalog: ITM3686
- Gene/Protein: MLKL
- Product Description: Immunotag™ MLKL mouse Monoclonal Antibody(8H7)
405.0000
Price in reward points: 405
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | MLKL (8H7) |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p |
| Recommended Dilution | IHC 1:100-200 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Synthetic Peptide of MLKL |
| Specificity | MLKL protein detects endogenous levels of MLKL |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | MLKL |
| Accession No. | Q8NB16 Q9D2Y4 |
| Alternate Names | MLKL |
| Description | mixed lineage kinase domain like(MLKL) Homo sapiens This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015], |
| Protein Expression | Chondrocyte,Leukocyte,Lymph node, |
| Subcellular Localization | cytoplasm,cytosol,plasma membrane, |
| Protein Function | domain:The protein kinase domain is predicted to be catalytically inactive.,similarity:Belongs to the protein kinase superfamily.,similarity:Contains 1 protein kinase domain., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
| English_US |
|
| Danish |
|
| Dutch |
|
| English_UK |
|
| French |
|
| German |
|
| Spanish |
|
| Norwegian |
|
| Portuguese |
|
| Finnish |
|
| Swedish |
|
| Polish |
|