Datasheet |
|
Target Protein |
HSC8000 |
Clonality |
Polyclonal |
Storage/Stability |
-20°C/1 year |
Application |
WB,IHC-p |
Recommended Dilution |
WB 1:500-2000,IHC-p 1:50-300 |
Concentration |
1 mg/ml |
Reactive Species |
Human,Mouse,Rat |
Host Species |
Rabbit |
Immunogen |
Recombinant Protein of Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8) |
Specificity |
The antibody detects endogenous HSC70 protein |
Purification |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form |
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name |
HSPA8 HSC70 HSP73 HSPA10 |
Accession No. |
P11142 P63017 P63018 |
Alternate Names |
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8) |
Description |
heat shock protein family A (Hsp70) member 8(HSPA8) Homo sapiens This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011], |
Cell Pathway/ Category |
Spliceosome,MAPK_ERK_Growth,MAPK_G_Protein,Endocytosis,Antigen processing and presentation, |
Protein Expression |
Bone marrow,Brain,Cajal-Retzius cell,Cerebellum,Embryonic k |
Subcellular Localization |
ubiquitin ligase complex,Prp19 complex,extracellular space,intracellular,nucleus,nucleoplasm,spliceosomal complex,nucleolus,lysosomal membrane,late endosome,cytosol,plasma membrane,cell-cell ad |
Protein Function |
function:Chaperone. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co-chaperones.,induction:Constitutively synthesized.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the heat shock protein 70 family.,subcellular location:Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Interacts with HSPH1/HSP105. Interacts with IRAK1BP1 (By similarity). Interacts with PACRG and TSC2. Interacts with SV40 VP1.,tissue specificity:Ubiquitous., |
Usage |
For Research Use Only! Not for diagnostic or therapeutic procedures. |