Datasheet |
|
Target Protein |
JAK1 |
Clonality |
Polyclonal |
Storage/Stability |
-20°C/1 year |
Application |
IHC-p |
Recommended Dilution |
IHC-p 1:50-300 |
Concentration |
1 mg/ml |
Reactive Species |
Human,Mouse,Rat |
Host Species |
Rabbit |
Immunogen |
Recombinant Protein of JAK1 |
Specificity |
The antibody detects endogenous JAK1 protein |
Purification |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form |
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name |
JAK1 JAK1A JAK1B |
Accession No. |
P23458 P52332 |
Alternate Names |
Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1) |
Description |
Janus kinase 1(JAK1) Homo sapiens This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016], |
Cell Pathway/ Category |
Jak_STAT,Pathways in cancer,Pancreatic cancer, |
Protein Expression |
Brain,Colon tumor,Kidney,Lung,Uterus, |
Subcellular Localization |
nucleus,cytoplasm,cytosol,cytoskeleton,focal adhesion,endomembrane system,membrane,extrinsic component of cytoplasmic side of plasma membrane, |
Protein Function |
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,domain:Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1.,domain:The FERM domain mediates interaction with JAKMIP1.,function:Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.,sequence caution:Translation N-terminally extended.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.,similarity:Contains 1 FERM domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,subcellular location:Wholly intracellular, possibly membrane associated.,subunit:Interacts with IL31RA, JAKMIP1 and SHB.,tissue specificity:Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue., |
Usage |
For Research Use Only! Not for diagnostic or therapeutic procedures. |